A synthetic Calvin cycle enables autotrophic growth in yeast
Thomas Gassler, Michael Sauer, Brigitte Gasser, Diethard Mattanovich, Matthias G. Steiger
This paper demonstrates that metabolic engineering can convert the yeast Pichia pastoris from heterotrophic to autotrophic growth by rewiring its carbon assimilation pathway to resemble the Calvin-Benson-Bassham cycle.
bioRxiv · Dec 3, 2019 · PreprintSynthetic Biology