Diethard Mattanovich

This study improves carbon efficiency in autotrophic yeast by redirecting methanol dissimilation through alcohol dehydrogenase, increasing biomass yield and product titers.

This study improves autotrophic growth of engineered Komagataella phaffii through strain optimization and process parameter adjustment, achieving up to 50% faster growth.

This study develops a synthetic autotrophic yeast strain that produces itaconic acid from CO2, achieving high titers through integrated pathway and process design.

This study engineers Komagataella phaffii to produce itaconic acid from methanol, achieving titers of 55 g/L and a yield of 0.24 g/g.

This paper demonstrates that metabolic engineering can convert the yeast Pichia pastoris from heterotrophic to autotrophic growth by rewiring its carbon assimilation pathway to resemble the Calvin-Benson-Bassham cycle.