Author

Yuanbao Ai

Hubei University of TechnologyORCID 0000-0002-9008-2884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Sen LiuiD· 2 shared Jinzhu LiiD· 1 shared Juanping WangiD· 1 shared Shuai Zhang· 1 shared Siyu Xu· 1 shared Xiaoyu ShiiD· 1 shared Yan ZhangiD· 1 shared Yutong Jiao· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

Sen LiuORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Pharmacology & ToxicologyBioorganic ChemistryPeer-reviewedAug 29, 2025

SUMO E1 covalent allosteric inhibitors modulate polyamine synthesis via the MAT2A-AdoMetDC axis

Shuai Zhang, Jinzhu Li, Zhiying Wang…·Sen Liu

The paper identifies SUMO E1 covalent allosteric inhibitors that modulate polyamine synthesis through the MAT2A-AdoMetDC axis and show synergistic effects with polyamine inhibitors in T47D cells.

2 citations

humanexperimental assay

Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewedJul 18, 2025

High-efficiency discovery and structure-activity-relationship analysis of non-substrate-based covalent inhibitors of S-adenosylmethionine decarboxylase

Yuanbao Ai, Siyu Xu, Yan Zhang…·Sen Liu

This study enhances a computational protocol for discovering covalent inhibitors of AdoMetDC by integrating quantum chemistry calculations, achieving a 70.6% hit rate in screening 17 compounds.

3 citations

deep learningstatistical model