Sen Liu

This study identifies a seesaw configuration of the ODC-OAZ1-AZIN1 axis that determines breast cancer cell sensitivity to polyamine-targeting inhibitors, offering a framework for personalized therapy.

This paper uses an optogenetic yeast model to decouple ODC inhibition and degradation, revealing that polyamine oscillation is essential for cell cycle progression.

The paper identifies SUMO E1 covalent allosteric inhibitors that modulate polyamine synthesis through the MAT2A-AdoMetDC axis and show synergistic effects with polyamine inhibitors in T47D cells.

This study enhances a computational protocol for discovering covalent inhibitors of AdoMetDC by integrating quantum chemistry calculations, achieving a 70.6% hit rate in screening 17 compounds.

This study identifies EPHA4 signaling dysregulation as a contributor to idiopathic scoliosis by linking it to locomotion defects and CPG network disruption in zebrafish.

The paper identifies a novel SOX9 variant in the TAM domain linked to axial skeletal dysplasia and scoliosis, showing reduced protein stability and recapitulating human phenotypes in mice.

This study shows that AlphaFold2 and RoseTTAfold models show structural variations correlated with protein foldability, independent of secondary structure and unrelated to function.

This study establishes an AD mouse model using bilateral hippocampal STZ injection, showing impaired learning/memory and altered synaptic plasticity with changes in protein expression and inflammatory response.

The paper investigates how different FBN1 truncating mutations cause distinct clinical phenotypes in Marfan syndrome and Marfanoid-progeroid-lipodystrophy syndrome through molecular and genetic analysis.