Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis
Alexis Ruiz, Sofia Benucci, Hervé Meier, G. V. Schulz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato
This study shows that reduced RyR1 in muscle spindles of mice with recessive Ryr1 mutations causes proprioception issues and scoliosis.
The Journal of Physiology · Oct 15, 2025Peer-reviewedPhysiology