Fabrizio Musacchio

Robust geometric drift correction and identity reconstruction for biological 3D time-lapse point clouds

This paper develops a method for correcting geometric drift and reconstructing identities in 3D time-lapse point cloud data using synthetic and biological datasets.

Inhibitory budget matching constrains homeostatic plasticity in competitive spiking networks

This paper shows that inhibitory plasticity in competitive spiking networks requires a matched inhibitory budget to maintain stability and performance, unlike fixed inhibition.

Toward standardized behavioral analysis in IntelliCage experiments

The paper introduces ic-analysis, an open-source toolkit for standardized IntelliCage behavioral analysis, demonstrating its ability to recover behavioral differences in a synthetic experiment.

ZenReg: A modular Python platform for fast and memory-efficient N-dimensional microscopy image registration

ZenReg is a Python platform for N-dimensional microscopy image registration that improves motion correction accuracy and efficiency in biological data.

Spectral Unmixing: A modular and reproducible Python package for directed and blind spectral unmixing in multidimensional microscopy stacks

The paper introduces a Python package for reproducible spectral unmixing in microscopy data, demonstrating improvements in bleed-through correction across different unmixing methods.

OMIO: A policy-driven Python library for reproducible microscopy image I/O

OMIO provides a policy-driven Python library to standardize microscopy image I/O, ensuring reproducible and interoperable data handling across formats and workflows.

CellColoc: A modular, open-source workflow for cell colocalization, segmentation, and feature extraction in microscopy images

Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone

This study uses three-photon imaging to examine microglia-glioblastoma interactions in a mouse model, revealing a biphasic response and directional movement of microglia toward tumor cells.

MotilA - A Python pipeline for the analysis of microglial fine process motility in 3D time-lapse multiphoton microscopy data

MotilA quantifies microglial fine process motility in 3D time-lapse microscopy data using a pixel-based change detection strategy, providing biologically interpretable metrics like turnover rate.

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

This paper demonstrates three-photon in vivo imaging in the mouse medial prefrontal cortex to achieve sub-cellular resolution of neuronal and glial activity at unprecedented depths.

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

This study shows that ADF/Cfl1 deficiency in microglia reduces motility and impairs memory by affecting cytoskeleton dynamics.

The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb

This study shows that HDB projections to the olfactory bulb modulate odor-evoked responses and are critical for olfactory-mediated habituation and discrimination behaviors.