Martin Fuhrmann

Robust geometric drift correction and identity reconstruction for biological 3D time-lapse point clouds

This paper develops a method for correcting geometric drift and reconstructing identities in 3D time-lapse point cloud data using synthetic and biological datasets.

Inhibitory budget matching constrains homeostatic plasticity in competitive spiking networks

This paper shows that inhibitory plasticity in competitive spiking networks requires a matched inhibitory budget to maintain stability and performance, unlike fixed inhibition.

Toward standardized behavioral analysis in IntelliCage experiments

The paper introduces ic-analysis, an open-source toolkit for standardized IntelliCage behavioral analysis, demonstrating its ability to recover behavioral differences in a synthetic experiment.

ZenReg: A modular Python platform for fast and memory-efficient N-dimensional microscopy image registration

ZenReg is a Python platform for N-dimensional microscopy image registration that improves motion correction accuracy and efficiency in biological data.

Spectral Unmixing: A modular and reproducible Python package for directed and blind spectral unmixing in multidimensional microscopy stacks

The paper introduces a Python package for reproducible spectral unmixing in microscopy data, demonstrating improvements in bleed-through correction across different unmixing methods.

OMIO: A policy-driven Python library for reproducible microscopy image I/O

OMIO provides a policy-driven Python library to standardize microscopy image I/O, ensuring reproducible and interoperable data handling across formats and workflows.

CellColoc: A modular, open-source workflow for cell colocalization, segmentation, and feature extraction in microscopy images

Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models

This paper develops an endothelial graft-enhanced CAM tumor model to study T cell recruitment and activation in human cancer immunotherapy.

PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities

The paper introduces PinkyCaMP, a new red fluorescent calcium sensor with improved brightness, photostability, and compatibility with optogenetics and neurotransmitter imaging.

Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone

This study uses three-photon imaging to examine microglia-glioblastoma interactions in a mouse model, revealing a biphasic response and directional movement of microglia toward tumor cells.

MotilA - A Python pipeline for the analysis of microglial fine process motility in 3D time-lapse multiphoton microscopy data

MotilA quantifies microglial fine process motility in 3D time-lapse microscopy data using a pixel-based change detection strategy, providing biologically interpretable metrics like turnover rate.

Molecular determinants of brain-resident CD8+ T cell formation and function

This study identifies molecular factors shaping brain-resident CD8+ T cell formation and function in health and disease.

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

This paper demonstrates three-photon in vivo imaging in the mouse medial prefrontal cortex to achieve sub-cellular resolution of neuronal and glial activity at unprecedented depths.

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

This study shows that ADF/Cfl1 deficiency in microglia reduces motility and impairs memory by affecting cytoskeleton dynamics.

CX3CR1 modulates migration of resident microglia towards brain injury

This study shows that CX3CR1 deficiency enhances microglial migration towards brain injury, suggesting it as a potential therapeutic target for CNS injuries.

Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

The paper reports that common AAV transduction procedures can induce artefactual Ca2+ micro-waves in the hippocampus and provides an alternative method to avoid this issue.

Microglia motility depends on neuronal activity andpromotes structural plasticity in the hippocampus

This study shows that microglia motility depends on neuronal activity and promotes synaptic plasticity in the hippocampus of awake mice.

sDarken: Next generation genetically encoded fluorescent sensors for serotonin

The paper introduces sDarken, a new family of genetically encoded serotonin sensors, demonstrating their effectiveness in imaging serotonin dynamics with high resolution.

Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes

This study shows that elevated C4 expression in the mouse prefrontal cortex causes schizophrenia-like phenotypes including synaptic and cognitive deficits.

Hippocampal hyperactivity in a rat model of Alzheimers disease

The paper investigates hippocampal neuronal activity in a rat Alzheimer's disease model, finding hyperactivity and intrinsic excitability changes in CA1 neurons before synaptic inhibition is affected.

The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb

This study shows that HDB projections to the olfactory bulb modulate odor-evoked responses and are critical for olfactory-mediated habituation and discrimination behaviors.

Label-free characterization of Amyloid-β-plaques and associated lipids in brain tissues using stimulated Raman scattering microscopy

This study uses stimulated Raman scattering microscopy to characterize amyloid-β plaques and associated lipids in AD mouse brain tissue, revealing structural and compositional features of pathological deposits.

Memory trace superimposition impairs recall in a mouse model of AD

The paper shows that in a mouse model of AD, memory recall is impaired due to the superimposition of new neurons onto the memory trace during retrieval.

Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model

The paper restores memory in Alzheimer’s disease mice by optogenetically synchronizing hippocampal theta oscillations.