Frank Bradke

A low-adhesion mechanism enables axon growth in the developing brain

This study identifies a low-adhesion mechanism driven by microtubule stabilization that enables rapid axon growth in the developing mouse brain.

Voluntary engagement predicts recovery across rehabilitation time points after experimental spinal cord injury

This study identifies factors influencing rehabilitation effectiveness after spinal cord injury, finding that voluntary engagement promotes recovery while forced training may reduce benefits.

Microtubule Stabilization and Biomaterial Guidance Synergize to Enhance CST Regeneration and Motor Recovery After Chronic SCI.

This study combines biomaterial scaffolds and microtubule stabilizers to improve axon regeneration and motor recovery in chronic spinal cord injury.

Slowdown of microtubule retrograde flow enables axon and dendrite development and maintenance

The paper shows that slowing microtubule retrograde flow is essential for axon and dendrite development and maintenance through a unified mechanism.

Nanoscale dendritic shaft constrictions shape synaptic integration in fine caliber principal neuron dendrites

The paper shows that dendrites have nanoscale constrictions that create electrical compartments, altering synaptic integration in neurons.

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

This paper demonstrates three-photon in vivo imaging in the mouse medial prefrontal cortex to achieve sub-cellular resolution of neuronal and glial activity at unprecedented depths.

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

This study shows that ADF/Cfl1 deficiency in microglia reduces motility and impairs memory by affecting cytoskeleton dynamics.

Microtubule retrograde flow retains neuronal polarization in a fluctuating state

The paper reveals that microtubule retrograde flow in developing neurons maintains a fluctuating state, which is essential for neuronal polarization by stabilizing microtubule density cycles before axon formation.