This study identifies high WEE1 expression as a prognostic marker in multiple myeloma, showing it is independently linked to poor survival and associated with dysregulated P53 pathways.

Blood Cancer Journal · Feb 20, 2025Peer-reviewedCancer Biology

Copy number signatures predict chromothripsis and associate with poor clinical outcomes in patients with newly diagnosed multiple myeloma

Kylee H. Maclachlan, Even Holth Rustad, Andriy Derkach, Binbin Zheng-Lin, Venkata D. Yellapantula, Benjamin T. Diamond, Malin L. Hultcrantz, Bachisio Ziccheddu, Eileen Mary Boyle, Patrick Blaney, Niccolò Bolli, Yanming Zhang, Ahmet Doǧan, Alexander M. Lesokhin, Gareth John Morgan, , Francesco Maura

This study shows copy number signatures predict chromothripsis in multiple myeloma and link to poor clinical outcomes using whole genome and exome sequencing data.

Nature Communications · Aug 27, 2021Peer-reviewedGenomics

Revealing the impact of recurrent and rare structural variants in multiple myeloma

Even Holth Rustad, Venkata D. Yellapantula, Dominik Głodzik, Kylee H. Maclachlan, Benjamin T. Diamond, Eileen Mary Boyle, Cody Ashby, Patrick Blaney, Gunes Gundem, Malin L. Hultcrantz, Daniel A. Leongamornlert, Nicos Angelopoulos, Daniel Auclair, Yanming Zhang, Ahmet Doǧan, , Francesco Maura

This study identifies 100 SV hotspots and 31 new candidate driver genes in multiple myeloma, revealing that 63% of SVs remain unexplained and are associated with outlier gene expression.

bioRxiv · Dec 18, 2019 · PreprintGenomics