Identification of small-molecule adjuvants that enhance the sensitivity of Escherichia coli to nitrofurantoin: Roles of Lon and MarA
Santhi Sanil Nandini, Pritam Saha, Rithika Shri, Pragyee Sharma, Sirisha Jagdish, Balaram Khamari, Sobhan Sen, Eswarappa Pradeep Bulagonda, Dipankar Nandi
This study identifies small-molecule adjuvants, specifically salicylates, that enhance nitrofurantoin's efficacy against Escherichia coli by modulating Lon protease and MarA pathways.
bioRxiv · Jan 18, 2026 · PreprintMicrobiology