BioinformaticsbioRxivPreprint
A Multi-modal LLM-Knowledge Fusion Framework for Predicting Single-cell Genetic Perturbation Effects
Mingkun Lu, Nanxin You, Hongning Zhang…·Y Zhou
scPert predicts single-cell transcriptomic responses to genetic perturbations by integrating large language model embeddings and biological knowledge, improving accuracy in both single-gene and combinatorial perturbations.