Author

Ling Xu

Howard Hughes Medical InstituteORCID 0000-0002-9057-0829Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ling Xu2 papers · Fujian Academy of Agricultural Sciences

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Anna Marie PyleiD· 2 shared Alisia PaniD· 1 shared Gina BucheliD· 1 shared Harim JangiD· 1 shared Kevin ChungiD· 1 shared Rong Guo· 1 shared Yu-Chieh SungiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

Anna Marie PyleORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 19, 2026

Heteromeric LGP2-MDA5 receptor complexes drive antiviral signaling

Gina Buchel, Ling Xu, Yu-Chieh Sung, Anna Marie Pyle

This study shows LGP2 is not just a recruitment factor for MDA5 but becomes an integral part of MDA5 filaments, stabilizing them and reducing the number of MDA5 molecules needed for signaling.

DOI 10.64898/2026.08.20.745998

experimental assay

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedSep 22, 2026

Establishing the molecular basis for MDA5 mutation-linked autoimmunity

Ling Xu, Harim Jang, Kevin Chung…·Anna Marie Pyle

This study identifies how a MDA5 mutation disrupts ATPase activity, leading to aberrant interferon signaling and autoimmunity.

DOI 10.1093/nar/gkag941

humanprotein structure

𝕏 PostBluesky