Anna Marie Pyle

This paper develops a RIG-I reporter mouse model to track RIG-I expression and function in vivo, revealing its tissue distribution and identifying alveolar macrophages as key sensor cells.

This study shows LGP2 is not just a recruitment factor for MDA5 but becomes an integral part of MDA5 filaments, stabilizing them and reducing the number of MDA5 molecules needed for signaling.

SLR14, an immunomodulatory RIG-I agonist, provides broad-spectrum antiviral protection against multiple highly pathogenic negative-sense RNA viruses in vitro and in vivo.

This study predicts the in cellulo secondary structure of HOTAIR in breast cancer cells and identifies conserved structural features across primates.

This study identifies how a MDA5 mutation disrupts ATPase activity, leading to aberrant interferon signaling and autoimmunity.

This study identifies RNA structures in Ebola virus mRNAs critical for infection and shows they can be targeted by antisense oligonucleotides.

This study investigates the interdependent role of four pseudoknots in the 3'-terminus of the West Nile virus genome and their impact on viral growth and sfRNA formation.

The paper introduces PCanPIE, a group I intron-based system for efficient circRNA synthesis at ambient temperatures, showing high circularization efficiency with optimized spacer sequences.

The paper determines the structure of lncRNA Pnky and identifies structured regions involved in neural stem cell differentiation.

The paper develops a computational pipeline to align noncoding RNAs across primate genomes, revealing conserved secondary structural motifs despite rapid evolutionary divergence.

The paper shows that activating RIG-I in macrophages enhances immunotherapy for glioblastoma by repolarizing tumor-associated macrophages and boosting anti-tumor immune responses.

This paper introduces UltraMarathonRT for scRNA-seq, revealing new transcriptomic features and demonstrating its utility in capturing additional genes and genomic elements.

The paper identifies a structured protein interaction hub in the long non-coding RNA NORAD using biochemical and sequencing methods.

US-align provides a universal platform for aligning diverse macromolecular structures, improving accuracy and speed in structural comparisons.

This study determines the complete secondary structure of the SARS-CoV-2 genome in infected cells, revealing novel regulatory motifs and conserved structural features across beta coronaviruses.

Time-course single-cell RNA sequencing of infected human bronchial epithelial cultures reports ciliated cells as a major target, with tropism later widening to basal and club cells.

The paper adapts R-scape to predict covariation in long mammalian lncRNAs, revealing structural conservation.