Author

Gina Buchel

Howard Hughes Medical InstituteORCID 0000-0001-5266-2477Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aleksei E. MikhalchenkoiD· 1 shared Amy KoskiiD· 1 shared Angelica Zamudio‐OchoaiD· 1 shared Anna María CalderóniD· 1 shared Anna Marie PyleiD· 1 shared Dmitry TemiakoviD· 1 shared Hsin‐Yao TangiD· 1 shared Li LiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Aleksei E. MikhalchenkoORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 19, 2026

Heteromeric LGP2-MDA5 receptor complexes drive antiviral signaling

Gina Buchel, Ling Xu, Yu-Chieh Sung, Anna Marie Pyle

This study shows LGP2 is not just a recruitment factor for MDA5 but becomes an integral part of MDA5 filaments, stabilizing them and reducing the number of MDA5 molecules needed for signaling.

DOI 10.64898/2026.08.20.745998

experimental assay

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Molecular BiologyNature GeneticsPeer-reviewedSep 18, 2023

Molecular Basis for Maternal Inheritance of Human Mitochondrial DNA

William Lee, Angelica Zamudio‐Ochoa, Gina Buchel…·Dmitry Temiakov

The paper identifies the molecular mechanism by which human sperm mitochondria lack mtDNA and how TFAM re-localization leads to paternal mtDNA elimination.

111 citationstop 1%

humanDNA methylation

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