CRISPR-Engineered hiPSC-derived Cardiomyocytes Reveal Divergent Responses to Loss and Defective Processing of A-type Lamins
Lauran Vandeweyer, E Garrido-Huescar, Mirthe Vandenputte, Bert Vandendriessche, Maaike Alaerts, Laura Ordovás, Bart Loeys, Winnok Harald De Vos
This study compares the effects of lamin A/C loss and defective prelamin A processing in cardiomyocytes using CRISPR-engineered hiPSC-derived cells, revealing shared and distinct stress responses.
bioRxiv · Jun 30, 2026 · PreprintCell Biology