Bart Loeys

This study compares the effects of lamin A/C loss and defective prelamin A processing in cardiomyocytes using CRISPR-engineered hiPSC-derived cells, revealing shared and distinct stress responses.

This study investigates how the maternal environment affects cardiovascular traits in MFS offspring using a mouse model, finding maternal inheritance leads to earlier aortic enlargement and persistent cardiac issues.

This study uses long-read sequencing and optical genome mapping to fully characterize unresolved structural variants, achieving single-basepair resolution and improving diagnostic yield.

This study uses a computational framework to analyze genetic data from 77,539 genomes, identifying 21 novel genetic associations with 269 rare diseases.