Winnok Harald De Vos

This study compares the effects of lamin A/C loss and defective prelamin A processing in cardiomyocytes using CRISPR-engineered hiPSC-derived cells, revealing shared and distinct stress responses.

This study shows that KCNQ2 loss-of-function causes early hyperexcitability and network remodeling in human neurons, with biphasic changes in function, gene expression, and structure.

This study shows that DRP1 depletion protects NK cells from hypoxia-induced dysfunction by preserving mitochondrial function and cytotoxic activity.

The paper shows that radiation-induced DNA damage in human forebrain organoids leads to microcephaly through a human-specific p53-E2F4 repression of microcephaly genes.

This study investigates altered spatiotemporal dynamics of resting-state networks in a Huntington's disease mouse model using dynamic functional connectivity and identifies age- and genotype-specific quasi-periodic patterns of brain activity.

PAC-MAP improves nucleus detection in dense 3D cell systems by predicting centroid positions and proximity, achieving high recall and F1 scores in spheroids and organoids.

This paper demonstrates the effectiveness of a membrane-aerated biofilm reactor (MABR) for nitrogen removal from urine using partial nitritation/anammox, achieving high removal rates and efficiencies over 335 days.

The paper develops an imaging assay with CNNs to accurately identify cell types in dense mixed neural cultures, outperforming time-based classification and enabling quality control of iPSC-derived models.

The paper identifies S100A8-enriched microglia in tauopathy and accelerated aging mouse models, showing their presence in human AD and tauopathy biopsies.

The paper characterizes NMU-expressing neurons in the adult mouse brain using a Nmu-Cre knock-in model, revealing a midline modulatory circuit centered on the VMH.

The paper investigates how human and bacterial amyloids affect enteric glia and smooth muscle cells, finding they trigger a pro-inflammatory response and DNA damage.

The paper develops an automated image analysis pipeline to quantify sarcopenia in C. elegans and establishes a model predicting biological age based on morphological muscle features.

The paper develops a proximity ligation-based method to improve synapse quantification in neuronal cultures by reducing false positives and increasing sensitivity.

This study uses DREADDs to inhibit neurons in the mouse anterior cingulate area and shows changes in functional connectivity and BOLD signals using fMRI.

The paper develops a microscopy-based pipeline to quantify neuronal network connectivity and identifies compounds that enhance connectivity and provide neuroprotection.

This study examines how the absence of FMRP affects neuronal network development in an in vitro model, finding that network-level changes are more pronounced than single-cell alterations.