CHRONIC LUNG INFLAMMATION LEADS TO MYELOID SKEWING OF HEMATOPOIETIC STEM CELLS IN A CYSTIC FIBROSIS MOUSE MODEL
Cássia Lisboa Braga, Rubia Isler Mancuso, Evrett N. Thompson, Hasan H. Öz, Ravindra Gudneppanavar, Ping-Xia Zhang, Pamela Huang, Thomas S. Murray, Marie E. Egan, Diane S. Krause, Emanuela M. Bruscia
This study shows chronic lung inflammation in a CF mouse model increases myeloid bias in hematopoietic stem cells, which persists even after inflammation resolves.
bioRxiv · Aug 2, 2024 · PreprintImmunology