Diane S. Krause

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

This study shows that double knockout of Vps13a and Vps13c in mice causes embryonic lethality due to impaired hematopoiesis and innate immune activation.

This study shows emerin, a nuclear envelope protein, is expressed in red blood cells and regulates membrane structure and function, with mutations linked to RBC phenotypes like MCV.

This study shows that the RBM15-MKL1 fusion protein drives leukemia through m6A methylation and WNT pathway activation, with METTL3 inhibition reducing tumor growth.

This study shows chronic lung inflammation in a CF mouse model increases myeloid bias in hematopoietic stem cells, which persists even after inflammation resolves.

The paper co-sequences microRNAs and mRNAs in single cells to show miRNA variability contributes to non-genetic cell-to-cell heterogeneity and identifies new regulatory relationships.