Intrinsic BMP inhibitor Gremlin regulates lung alveolar progenitor cell proliferation and differentiation
Toyoshi Yanagihara, Quan Zhou, Kazuya Tsubouchi, Spencer D. Revill, Anmar Ayoub, Sy Giin Chong, Anna Dvorkin‐Gheva, Kjetil Ask, Wei Shi, Martin R.J. Kolb
This study shows that Gremlin, an inhibitor of BMP, promotes AT2 cell proliferation and differentiation into AT1s during lung injury, facilitating alveolar repair.
bioRxiv · Jul 18, 2022 · PreprintMolecular Biology