Joshua M. Borin

Design, optimization, and inference of biphasic decay of infectious virus particles

This paper develops methods to detect and optimize sampling for multiphasic virus decay, applying them to show that 94% of phage ΦD9 decays 16-fold faster than the remaining population.

Bacteriophage {Phi}21s receptor-binding protein evolves new functions through destabilizing mutations that generate non-genetic phenotypic heterogeneity

This study shows that bacteriophage Φ21 evolves new host receptor usage through destabilizing mutations that create non-genetic phenotypic heterogeneity in viral particles.