Kevin D. Corbett

The paper identifies a bacterial pathway, Cerberus, that uses DNA damage sensing to regulate defense operon expression through anti-sigma factor cleavage.

This study identifies Rhc as a multifunctional protein essential for DNA replication and transcription in nucleus-forming phages, revealing its role in resolving R-loops and coordinating gene expression.

This study identifies a unique DNA replication mechanism in the chimallivirus PhiKZ, where a sliding clamp-derived protein enhances polymerase activity through a transient interaction.

The paper identifies a conserved protein interaction between axis core proteins and cohesin complexes in fungi and plants, revealing a mechanism for meiotic chromosome architecture.

The paper shows phosphorylation remodels centrosome matrix proteins to create docking sites for gamma-tubulin complexes, enabling microtubule nucleation during mitosis.

The paper defines how the CapP peptidase is activated by single-stranded DNA, leading to transcriptional activation of immune operons in response to DNA damage.

This study identifies a chromatin-associated pool of Aurora A regulated by TPXL-1 that ensures proper chromosome biorientation by stabilizing kinetochore-microtubule attachments.

The paper determines the high-resolution structure of the Chimalliviridae phage Goslar, revealing its host recognition and infection machinery through cryo-EM and mass spectrometry.

This paper engineers OAA lectins to selectively bind specific high mannose glycans, enhancing sensitivity and applicability in glycan profiling and antiviral applications.

The paper identifies CapK and CapS proteins that regulate immune operon expression in response to DNA damage in bacteria.

This study identifies SYCP2's closure motif as essential for HORMAD2 recruitment to chromosome axes, revealing its role in meiotic synapsis quality control in mice.

This study reveals the conformational dynamics of Tom70 through structural and computational analyses, showing how its allosteric network coordinates mitochondrial protein import and is modulated by viral interactions.

This study characterizes the Bub bacterial ubiquitination-like pathway, revealing its unique biochemical mechanisms and structural similarities to eukaryotic ubiquitination.

The paper determines the structure of meiotic HORMAD CBRs from two holozoa, showing their chromatin binding mechanism and potential histone modification discrimination.

This study identifies how TRIM37 prevents ectopic spindle pole formation by recognizing peptide motifs in centrobin and undergoing substrate-dependent oligomerization.

The paper identifies the axis-central region interface in the synaptonemal complex of C. elegans and shows that liquid-like assembly occurs through wetting without active energy consumption.

The paper shows that short 5' UTRs in viral mRNAs are recognized by the IFIT2-IFIT3 complex, leading to translation inhibition and antiviral activity.

This study identifies a bacterial NLR-related protein that detects phage infection through a conserved interface, triggering programmed cell death to limit viral spread.

This study reveals that the bacterial SMC Wadjet complex uses loop extrusion to specifically recognize and cleave plasmid DNA, establishing loop extrusion as a conserved mechanism across SMC complexes.

This study identifies structural diversity and Ca2+-mediated oligomerization in bacterial ubiquitin-like proteins, suggesting a role in stress response.

This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

This study shows phosphorylation disrupts tau's ability to undergo phase separation and interact with chromatin, potentially contributing to nuclear dysfunction in Alzheimer's disease.

This study shows that bacteriophage Φ21 evolves new host receptor usage through destabilizing mutations that create non-genetic phenotypic heterogeneity in viral particles.

The paper identifies two pathways for meiotic chromosome axis assembly in yeast, showing cohesin-dependent and cohesin-independent mechanisms recruit axis proteins to genomic regions with high gene density.

The paper identifies conserved axis core proteins across species and shows they form filamentous structures essential for meiotic chromosome organization and recombination.