Daniel Han

This paper introduces a generative model of the connectome that simulates dynamic axon growth, producing brain-like network structures and revealing how axonal guidance principles shape macroscopic connectomes.

Annotating the 127,978-neuron FlyWire fly connectome yields 4,552 cell types, 3,094 cross-validated against the hemibrain; cell-type edges above 10 synapses or 1.1% of input recur over 90% across hemispheres.

The paper identifies spatially periodic HES5 microclusters in the mouse spinal cord during neurogenesis, showing their dynamic regulation by Notch signaling and their role in progenitor differentiation.