The open to closed D-loop conformational switch determines length in filopodia-like actin bundles
Jonathan R Gadsby, Pantelis Savvas Ioannou, Richard Butler, Julia Mason, Alison J. Smith, Ulrich Dobramysl, Stacey E. Chin, Claire Dobson, Jennifer L. Gallop
The paper identifies antibodies that lengthen filopodia-like actin bundles by stabilizing the open D-loop conformation of actin filaments, revealing a mechanism for regulating their length.
Biochemical Journal · Dec 2, 2024Peer-reviewedBiochemistry