Ulrich Dobramysl

The paper develops tools to annotate mRNA features in trypanosomatid parasites using RNA sequencing data and applies them to annotate UTRs across available genomes.

The paper introduces a Python module for accessing TrypTag data on protein subcellular localization in Trypanosoma brucei and demonstrates its use in analyzing age-based organelle composition differences.

The paper identifies 34 transporter genes essential for Leishmania promastigote survival in sand flies, with V-ATPase subunits critical for parasite differentiation and life cycle progression.

This study investigates SNX9's membrane binding and actin polymerization roles, finding it binds preferentially to PI(4,5)P2 and PI(3)P and forms diverse actin structures.

The paper identifies essential membrane transporters for Leishmania survival through a CRISPR-Cas9 gene deletion screen, finding that V-ATPase is critical for amastigote survival despite being dispensable for promastigote growth.

The paper identifies antibodies that lengthen filopodia-like actin bundles by stabilizing the open D-loop conformation of actin filaments, revealing a mechanism for regulating their length.

The paper shows integrin signaling suppresses filopodia in Drosophila myotubes during muscle-tendon attachment, enabling actin machinery to form strong attachments.