Disrupting ATXN1 Nuclear Localization in a Knock-in SCA1 Mouse Model Improves a Spectrum of SCA1-Like Phenotypes and their Brain Region Associated Transcriptomic Profiles
Hillary P. Handler, Lisa A. Duvick, Jason S. Mitchell, Marija Cvetanović, Molly Reighard, Alyssa Soles, Orion Rainwater, Shannah Serres, Tessa Nichols‐Meade, Stephanie L. Coffin, Yun You, Brian L. Ruis, Brennon L. O’Callaghan, Christine M. Henzler, Huda Yahya Zoghbi, Harry T. Orr
This study shows disrupting ATXN1 nuclear localization in a SCA1 mouse model reduces disease-like phenotypes and alters region-specific transcriptomic profiles.
bioRxiv · Dec 16, 2021 · PreprintNeuroscience