Brian L. Ruis

This study shows TET1 acts as a tumor suppressor in lung adenocarcinoma by promoting antitumor immunity and inhibiting cell proliferation and migration.

This study shows disrupting ATXN1 nuclear localization in a SCA1 mouse model reduces disease-like phenotypes and alters region-specific transcriptomic profiles.

This paper describes a split Staphylococcus aureus prime editor delivered by dual AAVs, demonstrating in vitro editing capacity despite lower-than-ideal efficiency.