Virginie Marty

The paper identifies DGKK as the primary target of SNORD116, showing increased DGKK RNA and protein levels upon SNORD116 depletion in human and mouse models.

The paper investigates the role of Snord116 and Snord115 genes in Prader-Willi syndrome using knockout mice and comparative genomics, finding their impact on growth, metabolism, and gene regulation.

This study shows that deleting SNORD115 reduces REM sleep abnormalities caused by SNORD116 deletion in PWS mouse models, revealing complex interactions between these SNORDs.