A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay
Thareendra De Zoysa, Alayna C. Hauke, Nivedita R. Iyer, Erin Marcus, Sarah M. Ostrowski, Franziska Stegemann, Dmitri N. Ermolenko, Justin C. Fay, Eric M. Phizicky
This paper shows that mutations in ribosomal protein genes suppress temperature sensitivity in S. pombe tRNA modification mutants by reducing ribosome concentrations, thereby decreasing tRNA demand and GAAC activation.
PLoS Genetics · Jan 31, 2024Peer-reviewedMolecular Biology