Thareendra De Zoysa

The paper uses chimeric eCLIP to map snoRNA-target RNA interactions, identifying novel interactions and regulatory roles in RNA biogenesis.

This paper shows that mutations in ribosomal protein genes suppress temperature sensitivity in S. pombe tRNA modification mutants by reducing ribosome concentrations, thereby decreasing tRNA demand and GAAC activation.

The paper shows that hypomodified tRNA in two yeast species triggers rapid tRNA decay, which activates the GAAC pathway, but with opposite effects on tRNA decay in each species.

The paper identifies a new pathway in yeast where pre-tRNAs are degraded by the RTD pathway after nuclear export due to structural instability and increased availability.