Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression
François-Xavier Blaudin de Thé, Hocine Rekaik, Eugénie Pezé-Heidsieck, Olivia Massiani-Beaudoin, Rajiv L. Joshi, Julia Fuchs, Alain Prochiantz
The paper shows that Engrailed-1 protects dopaminergic neurons from degeneration by repressing LINE-1 expression, which is linked to oxidative stress-induced DNA damage.
The EMBO Journal · Jun 25, 2018Peer-reviewedNeuroscience