Julia Fuchs

Interactions of the LINE-1 encoded ORF1p with proteins and chromatin converge on a role in neuronal physiology

This study identifies ORF1p interactions with proteins and chromatin in neurons, showing its role in gene regulation and neurite morphology.

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

The paper investigates LINE-1 ORF1p protein and RNA expression in mouse and human brains, finding increased levels with aging and neuron-specific expression patterns.

Nuclear translocation of LINE-1 ORF1p alters nuclear envelope integrity and disrupts nucleocytoplasmic transport in human neurons

This study shows that ORF1p from LINE-1 retrotransposons translocates to the nucleus under stress, disrupts nuclear envelope integrity, and contributes to neurodegenerative features in neurons.

Perturbed DNA methylation by sustained overexpression of Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death in mice

This study shows that sustained Gadd45b overexpression in mice causes DNA methylation changes, heterochromatin disorganization, DNA damage, and dopaminergic neuron death, linking chromatin alterations to neurodegeneration.

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression

The paper shows that Engrailed-1 protects dopaminergic neurons from degeneration by repressing LINE-1 expression, which is linked to oxidative stress-induced DNA damage.