Chao Xie

Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness

The paper develops a digital twin brain model that simulates and manipulates functional brain networks to predict mental illness symptoms and responses to interventions.

Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function

The paper identifies a genetic-dependent brain signature of resilience linked to childhood abuse and depression risk in girls, showing its predictive value for emotional disorders in adolescence and early adulthood.

GWAS of ~30,000 samples with bone mineral density at multiple skeletal sites and its clinical relevance on fracture prediction, genetic correlations and prioritization of drug targets

This study performs GWAS on BMD traits and fracture risk using 30,000 UK Biobank samples, identifies novel loci, and prioritizes drug targets for osteoporosis prevention.

Fractionation of neural reward processing into independent evaluation and salience components by novel decoding principle

This paper introduces DeCoP, a novel decoding method that separates reward processing into evaluation and salience components, showing improved performance over traditional methods.