Hou‐Feng Zheng

UK BioCoin enables trait-specific covariate adjustment for UK Biobank summary statistics without individual-level data, achieving high correlation with full GWAS results.

This study shows genetic liability to hip osteoarthritis protects against Alzheimer's disease through neurovascular mechanisms, but this protection is masked by depression-related comorbidity.

The paper introduces two LD estimation algorithms to create high-resolution LD grids across species, revealing evolutionary patterns and population structure.

This study performs GWAS on BMD traits and fracture risk using 30,000 UK Biobank samples, identifies novel loci, and prioritizes drug targets for osteoporosis prevention.

This paper introduces encG-reg, an encrypted genotype regression method that identifies relatives across cohorts without sharing raw data, achieving accuracy comparable to traditional methods.

The paper introduces SEAD, an Asian reference panel that improves rare variant imputation and GWAS analysis, identifying a novel association between SNTG1 and hip BMD.

This study shows that stac3 knockout in zebrafish mimics early life lipid overload and muscle weakness seen in Native American myopathy.

PAGEANT provides a framework for genetic reporting tools by analyzing genomic data to assess health risks and genetic traits, using publicly available genome datasets.

The paper presents genomic analyses of 10,376 Chinese individuals, identifying novel genetic variations and providing a reference haplotype map, along with an imputation server for improved accuracy.

The paper evaluates genotype imputation accuracy across Han Chinese and European populations using 394 reference panels, finding optimal diversity levels and highlighting the need for better Chinese reference panels.