Shimon Marom

Bounded Multiplicative Dynamics Govern Axonal Conduction Slowdown

The paper introduces a bounded multiplicative framework to explain axonal conduction slowdown, showing it accounts for the stability of the slowdown distribution across lengths.

Distributional invariance and proportional scaling in axonal conduction

The paper quantifies conduction velocity changes along axonal branches and finds a right-skewed distribution of velocity ratios that is invariant across branch lengths and neuron positions.

Dynamics of Excitability in Axonal Trees

The paper shows axons maintain high spike transmission fidelity under spontaneous activity but can fail under sustained 10 Hz stimulation, with simulations attributing this to sodium channel inactivation.

Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions

This study shows that slow inactivation of Na+ channels normalizes axonal firing reliability when channel distributions are uneven.

Dynamic clamp constructed phase diagram of the Hodgkin-Huxley action potential model

The paper experimentally validates the Hodgkin-Huxley phase diagram using dynamic clamp and Kv1.3 channels in Xenopus oocytes, revealing activity-dependent and hysteretic dynamics.