Eve E. Marder

The paper investigates how acclimation to different temperatures affects the robustness of neural rhythms in the lobster's stomatogastric nervous system, showing that warm-acclimated lobsters maintain rhythmic patterns over a broader temperature range.

The paper investigates how temperature affects neuromuscular function in the crab Cancer borealis and identifies compensatory mechanisms that maintain function across temperature changes.

The paper uses mass spectrometry to analyze neuropeptide changes in American lobsters under different temperatures, finding tissue-specific peptide abundance shifts linked to thermal adaptation.

This paper shows that stomach muscles of Cancer borealis hyperpolarize with warming and operate optimally within a narrow pH window, mediated by K2P channels that reduce excitability and maintain neuromuscular function under environmental change.

The paper demonstrates how neurons use dual-timescale regulation of ion channel properties to achieve persistent adaptation to environmental perturbations.

This paper introduces Recurrent Mechanistic Models (RMMs) for predicting neural dynamics, showing they can be trained quickly and are interpretable for small circuits.

The paper compares the robustness of neural circuits to changes in intrinsic versus synaptic conductances and finds that intrinsic conductances have greater sensitivity.

The paper investigates how voltage-dependent ion channel regulation and channel density changes interact to maintain stable neuronal activity over time.

The paper investigates how sulfonylurea receptor (SUR) conductances affect two central pattern generating circuits in Cancer borealis, showing opposite effects on neuronal firing in different circuits.

The paper investigates how the Ih current affects the pyloric rhythm's frequency and phase in response to temperature changes in Cancer borealis, revealing non-monotonic dynamics when Ih is blocked.

This study shows that slow inactivation of Na+ channels normalizes axonal firing reliability when channel distributions are uneven.

The paper shows that neuronal morphology enhances robustness to channel density perturbations by maintaining firing properties despite conductance variations.

The paper identifies synaptic integration sites and modulator release patterns in the cardiac ganglion of the crab, Cancer borealis, using immunohistochemical techniques.

The paper maps neural circuit dynamics across functional and dysfunctional states using statistical features of spike times in the pyloric circuit of C. borealis.

The paper investigates how two types of reciprocal inhibitory circuits respond differently to perturbations and modulation.

The paper models how axonal diameter, myelination, and Na/K pump density interact to affect resilience to high frequency spiking.

The paper develops a computational model to explain how neurons retain memory of past perturbations through hidden changes in conductance regulation.

The paper shows that temperature-dependent changes in rhythm frequency do not disrupt integer coupling between fast and slow oscillators in Cancer borealis.

The paper shows that different neural circuits producing similar rhythms respond differently to the same inputs, sometimes via distinct mechanisms.

The paper uses computational models of crab and lobster pyloric circuits to show how temperature changes the relative contributions of currents to rhythmic activity, allowing smooth adaptation across temperatures.

The paper investigates how elevated extracellular potassium affects neuronal activity in the crab pyloric circuit, revealing transient loss followed by recovery of spiking and bursting activity.

The paper experimentally validates the Hodgkin-Huxley phase diagram using dynamic clamp and Kv1.3 channels in Xenopus oocytes, revealing activity-dependent and hysteretic dynamics.

The paper shows that homeostatic plasticity mechanisms that compensate for cell size changes are vulnerable to channel deletions.

The paper evaluates how accurately transcriptional profiling can classify neuronal cell types using small crustacean ganglia, finding that expression profiles alone are insufficient without additional modalities.

The paper introduces visualization methods to analyze how ionic currents contribute to neuronal dynamics and how differences in conductance densities affect model behavior.

The paper investigates how neuronal morphology in the crustacean stomatogastric ganglion affects voltage signal propagation and summation, finding electrotonic uniformity and linear summation across four neuron types.

This study examines how temperature affects heart and pyloric rhythms in the crab Cancer borealis, finding that heart rhythms are more robust to high temperatures than pyloric rhythms.

This study examines how extreme pH changes affect two central pattern generators in the crab Cancer borealis, finding differential sensitivity between the stomatogastric and cardiac ganglia.

The paper shows that a crustacean pacemaker circuit is robust to temperature and pH perturbations, with consistent network state transitions despite high parameter variability.

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