MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repair
Cindy Khuu, Melody Malek, Savannah G. Conlon, Geoffrey P. Wadey, Carlos H. Trasviña‐Arenas, Sheila S. David
The paper assesses cancer-associated MUTYH variants in the interdomain connector, finding some impair DNA repair downstream of adenine excision while others affect lesion recognition.
ChemBioChem · Jul 10, 2026Peer-reviewedBiochemistry