Author

Carlos H. Trasviña‐Arenas

Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalORCID 0000-0002-9881-375XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

Sheila S. DavidiD· 5 shared Andrew J. FisheriD· 3 shared Melody MalekiD· 3 shared Mohammad Hashemian· 3 shared Abigayle F. VitoiD· 1 shared Alam X León Cardona· 1 shared April Lu· 1 shared Bret FreudenthaliD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBiochemistry

Sheila S. DavidORCID

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5 papers

Recent·Most cited

BiochemistryChemBioChemPeer-reviewedJul 10, 2026

MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repair

Cindy Khuu, Melody Malek, Savannah G. Conlon…·Sheila S. David

The paper assesses cancer-associated MUTYH variants in the interdomain connector, finding some impair DNA repair downstream of adenine excision while others affect lesion recognition.

DOI 10.1002/cbic.70412

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 30, 2026

Structural Connectivity Between the Zinc Linchpin Motif, the cluster, and the active site orchestrates DNA repair in MUTYH

Mohammad H. Hashemian, Melody Malek, Tian Xia…·Sheila S. David

This study presents MUTYH crystal structures showing how the Zn linchpin and Fe-S cluster interact to facilitate DNA repair, revealing how mutations disrupt this process.

DOI 10.64898/2026.05.27.728240

humanstructural biology

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedNov 13, 2025

Crystal structure of MutYX: A novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-Oxoguanine recognition sphere

Carlos H. Trasviña‐Arenas, Mohammad Hashemian, Melody Malek…·Sheila S. David

The paper determines the crystal structure of MutYX, a clusterless adenine DNA glycosylase, revealing structural adaptations that enable OG recognition without a [4Fe-4S] cofactor.

1 citation

protein structureexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintSep 2, 2025

Structure, dynamics, and processing of 8oxoG:A in the nucleosome

Abigayle F. Vito, Justin A. Ling, Julia C. Ferrara…·Bret Freudenthal

This study determines the structure and dynamics of 8oxoG:C and 8oxoG:A base pairs in the nucleosome and characterizes MUTYH activity, revealing that 8oxoG:A is less processable by MUTYH.

DOI 10.1101/2025.09.02.673820

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedApr 15, 2025

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its cluster cofactor and active site required for DNA repair

Carlos H. Trasviña‐Arenas, Upeksha C. Dissanayake, Nikole Tamayo…·Sheila S. David

The paper investigates the role of the [4Fe-4S] cofactor in MUTYH DNA repair by analyzing cancer variants and solving the enzyme's crystal structure.

21 citationstop 2%

humanstructural biology

𝕏 PostBluesky