Author

Melody Malek

University of California, DavisORCID 0000-0002-1083-0791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein structure· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Carlos H. Trasviña‐ArenasiD· 3 shared Sheila S. DavidiD· 3 shared Andrew J. FisheriD· 2 shared Alam X León Cardona· 1 shared April Lu· 1 shared Cindy KhuuiD· 1 shared Geoffrey P. WadeyiD· 1 shared Mohammad H. HashemianiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

Carlos H. Trasviña‐ArenasORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repair

Cindy Khuu, Melody Malek, Savannah G. Conlon, Geoffrey P. Wadey, Carlos H. Trasviña‐Arenas, Sheila S. David

The paper assesses cancer-associated MUTYH variants in the interdomain connector, finding some impair DNA repair downstream of adenine excision while others affect lesion recognition.

ChemBioChem · Jul 10, 2026Peer-reviewedBiochemistry

Structural Connectivity Between the Zinc Linchpin Motif, the cluster, and the active site orchestrates DNA repair in MUTYH

Mohammad H. Hashemian, Melody Malek, Tian Xia, April Lu, Alam X León Cardona, Andrew J. Fisher, Carlos H. Trasviña‐Arenas, Sheila S. David

This study presents MUTYH crystal structures showing how the Zn linchpin and Fe-S cluster interact to facilitate DNA repair, revealing how mutations disrupt this process.

bioRxiv · May 30, 2026 · PreprintBiochemistry

Crystal structure of MutYX: A novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-Oxoguanine recognition sphere

Carlos H. Trasviña‐Arenas, Mohammad Hashemian, Melody Malek, Steven Merrill, Andrew J. Fisher, Sheila S. David

The paper determines the crystal structure of MutYX, a clusterless adenine DNA glycosylase, revealing structural adaptations that enable OG recognition without a [4Fe-4S] cofactor.

Nucleic Acids Research · Nov 13, 2025Peer-reviewedBiochemistry