Author
University of California, DavisORCID 0000-0001-5873-7935Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Cindy Khuu, Melody Malek, Savannah G. Conlon…·Sheila S. David
The paper assesses cancer-associated MUTYH variants in the interdomain connector, finding some impair DNA repair downstream of adenine excision while others affect lesion recognition.
L. Peyton Russelburg, Merve Demir, Karina Cedeno…·Martin P. Horvath
This study investigates the role of catalytic Glu43 in MutY's mechanism by analyzing variants and showing their impact on substrate conformation and product formation.
Mohammad H. Hashemian, Melody Malek, Tian Xia…·Sheila S. David
This study presents MUTYH crystal structures showing how the Zn linchpin and Fe-S cluster interact to facilitate DNA repair, revealing how mutations disrupt this process.
Carlos H. Trasviña‐Arenas, Mohammad Hashemian, Melody Malek…·Sheila S. David
The paper determines the crystal structure of MutYX, a clusterless adenine DNA glycosylase, revealing structural adaptations that enable OG recognition without a [4Fe-4S] cofactor.
Abigayle F. Vito, Justin A. Ling, Julia C. Ferrara…·Bret Freudenthal
This study determines the structure and dynamics of 8oxoG:C and 8oxoG:A base pairs in the nucleosome and characterizes MUTYH activity, revealing that 8oxoG:A is less processable by MUTYH.
Carlos H. Trasviña‐Arenas, Upeksha C. Dissanayake, Nikole Tamayo…·Sheila S. David
The paper investigates the role of the [4Fe-4S] cofactor in MUTYH DNA repair by analyzing cancer variants and solving the enzyme's crystal structure.