Author

Alfonso Santos-López

Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaORCID 0000-0002-9163-9947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

Álvaro San MillániD· 3 shared Coloma CostasiD· 3 shared Javier DelaFuenteiD· 3 shared Jorge Sastre-DomíngueziD· 3 shared Marta Hernández-GarcíaiD· 2 shared Paloma Rodera-FernandeziD· 2 shared Rafael CantóniD· 2 shared Aida Alonso-del ValleiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Álvaro San MillánORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 18, 2026

Genomic Characterization of the RyC collection: 50 Multidrug Resistant Clinical Isolates of Escherichia coli and Klebsiella spp.

Paloma Rodera-Fernandez, Jorge Sastre-Domínguez, Coloma Costas…·Álvaro San Millán

The paper characterizes a collection of 50 multidrug-resistant clinical isolates of Escherichia coli and Klebsiella spp., providing genomic insights into antimicrobial resistance and mobile genetic elements.

DOI 10.64898/2026.05.18.725816

E. coliwhole-genome sequencing

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MicrobiologyNature MicrobiologyPeer-reviewedMar 13, 2026

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Jorge Sastre-Domínguez, Paloma Rodera-Fernandez, Javier DelaFuente…·Álvaro San Millán

This study shows plasmids contribute to antimicrobial resistance by promoting gene inactivation via insertion sequences in Klebsiella pneumoniae.

8 citationstop 1%

E. coliwhole-genome sequencing

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MicrobiologybioRxivPreprintJan 22, 2025

History shapes regulatory and evolutionary responses to tigecycline in strains of Acinetobacter baumannii from the pre- and post-antibiotic eras

Alecia B. Rokes, Alfonso Santos-López, Vaughn S. Cooper

This study compares how two Acinetobacter baumannii strains from different eras respond to tigecycline, showing historical differences influence transcriptional responses and resistance adaptation mechanisms.

DOI 10.1101/2025.01.22.634413

bacteria (other)whole-genome sequencing

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MicrobiologyNature Ecology & EvolutionPeer-reviewedAug 28, 2024

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

Jorge Sastre-Domínguez, Javier DelaFuente, Laura Toribio-Celestino…·Álvaro San Millán

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

32 citationstop 2%

humanexperimental assay

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