Jorge Sastre-Domínguez

The paper characterizes a collection of 50 multidrug-resistant clinical isolates of Escherichia coli and Klebsiella spp., providing genomic insights into antimicrobial resistance and mobile genetic elements.

This study shows plasmids contribute to antimicrobial resistance by promoting gene inactivation via insertion sequences in Klebsiella pneumoniae.

This study measures the fitness effects of 136 antimicrobial resistance genes in changing environments and finds that oxygen availability modulates their cost.

This study investigates the role of NucS-mediated non-canonical mismatch repair in Mycobacterium tuberculosis and finds it does not significantly affect resistance to key antibiotics.

This study uses CRISPRi screens to analyze fitness effects of the pOXA-48 plasmid in clinical enterobacteria, identifying key genes and mechanisms affecting plasmid stability and transmission.

The paper investigates plasmid-chromosome transcriptional interactions in multidrug-resistant bacteria, finding that a plasmid-encoded regulator drives chromosomal operon overexpression, enhancing bacterial fitness and carbapenem resistance dissemination.

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.