Coloma Costas

The paper characterizes a collection of 50 multidrug-resistant clinical isolates of Escherichia coli and Klebsiella spp., providing genomic insights into antimicrobial resistance and mobile genetic elements.

This study shows plasmids contribute to antimicrobial resistance by promoting gene inactivation via insertion sequences in Klebsiella pneumoniae.

This study uses CRISPRi screens to analyze fitness effects of the pOXA-48 plasmid in clinical enterobacteria, identifying key genes and mechanisms affecting plasmid stability and transmission.

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.