Author

Richard M. Walsh

Harvard UniversityORCID 0000-0002-8939-8988Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

Adam Johnson· 1 shared Bing CheniD· 1 shared David Z RudneriD· 1 shared Doina AtanasiuiD· 1 shared Ekaterina E. Zheleznova HeldweiniD· 1 shared Emily P BalskusiD· 1 shared Fernando H Ramirez-GuadianaiD· 1 shared G. M. Jonaid· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

Adam Johnson

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4 papers

Recent·Most cited

Structure of Bacillus cereus ZmaM, a peptidase-ABC transporter that secretes and activates zwittermicin A

Gerardo E Zavala, José A Velilla, Richard M Walsh, Mit Patel, Karissa Mennes, Wasan Rafat, Miguel A Aguilar Ramos, Martin Daniel-Ivad, Fernando H Ramirez-Guadiana, David Z Rudner, Emily P Balskus, Rachelle Gaudet

The paper structures ZmaM, a type II peptidase-ABC transporter in B. cereus, showing it activates and exports zwittermicin A by coordinating peptidase and transporter modules.

bioRxiv · Nov 2, 2026 · PreprintMicrobiology

Effect of the S2' site cleavage on SARS-CoV-2 spike

Wei Kang Shi, G. M. Jonaid, Md. Golam Kibria, Jacob Allen, Hanqin Peng, Sophia Rits‐Volloch, Haisun Zhu, Shaowei Wang, Richard M. Walsh, Jianming Lu, Bing Chen

The paper reports a cryo-EM structure of the S2 fragment of SARS-CoV-2 after S2 cleavage, showing it represents a late fusion intermediate, and shows that S2 cleavage accelerates membrane fusion.

Nature Communications · Nov 27, 2025Peer-reviewedBiochemistry

Octahedral small virus-like particles of dengue virus type 2

Adam Johnson, Martín M. Dodes Traian, Richard M. Walsh, Simon Jenni, Stephen C. Harrison

The paper determines the cryo-EM structure of immature, small VLPs of dengue virus type 2, revealing octahedral symmetry and prM-E heterodimer clustering, with implications for vaccine design.

Journal of Virology · Dec 31, 2024Peer-reviewedMicrobiology

Allosteric mechanism of membrane fusion activation in a herpesvirus

Gonzalo L. González‐Del Pino, Richard M. Walsh, Doina Atanasiu, Tina M. Cairns, Wan Ting Saw, Gary H. Cohen, Ekaterina E. Zheleznova Heldwein

This study determines the pre-activation structure of the herpesvirus gH/gL complex and identifies an allosteric mechanism for transmitting fusion signals from gD to gB.

bioRxiv · Sep 20, 2024 · PreprintMicrobiology