Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor Emboli
Pritha PAI, Christophe Van Berckelaer, Steven Van Laere, Alexandra Bennion, Theresa Charity, Jin‐Ming Yang, François Bertucci, Peter Van Dam, Gregory M. Palmer, Shannon J. McCall, Luc Yves Dirix, Naoto Tada Ueno, Gayathri R. Devi
This study identifies macrophage infiltration and TNF-α signaling networks in IBC tumor emboli and shows that targeting these pathways with Birinapant inhibits tumor emboli in vivo.
The Breast · Aug 2, 2026Peer-reviewedCancer Biology