Steven Van Laere

Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor Emboli

This study identifies macrophage infiltration and TNF-α signaling networks in IBC tumor emboli and shows that targeting these pathways with Birinapant inhibits tumor emboli in vivo.

Tumor emboli-associated adaptive stress response signatures identify aggressive disease features in inflammatory breast cancer

This study identifies adaptive stress response (ASR) signatures in inflammatory breast cancer (IBC) that correlate with tumor emboli survival, dissemination, and therapeutic response.

DRP1 depletion protects NK cells against hypoxia-induced dysfunction

This study shows that DRP1 depletion protects NK cells from hypoxia-induced dysfunction by preserving mitochondrial function and cytotoxic activity.

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

This study profiles cell-free DNA in metastatic prostate cancer patients, identifying genomic alterations, microsatellite instability, and clonal hematopoiesis as potential biomarkers.