Saveez Saffarian

The paper uses cryo-electron tomography to compare Gag lattice structures in HIV-1 virus-like particles and immature virions, finding differences in lattice density, completeness, and curvature-Gag copy number correlation.

The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.

This paper introduces a method for purifying HIV virions with high yield and minimal force, enabling detailed structural analysis of virion maturation.

This study measures the kinetics of SARS-CoV-2 virus-like particle internalization using live-cell microscopy, revealing key steps and their timing, and showing no effect of Omicron mutations or S protein cleavage site on internalization rates.

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.