A mechanism-aware stoichiometry platform resolves functional viral thresholds and induces antiviral hypersensitivity
Gabe Clinger, Haley Durden, Aaron Daurelle, Benjamin Preece, Wiley Peppel, Rodrigo Gallegos, Abdul A. Waheed, Nicole Bohne, Brian MacArthur, Abby Peterson, Ahmet Yıldız, Eric O. Freed, Saveez Saffarian
The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.
bioRxiv · Feb 10, 2026 · PreprintBiophysics