Author

Haley Durden

University of UtahORCID 0000-0002-7401-4347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Rodrigo Gallegos· 4 shared Saveez SaffarianiD· 4 shared Wiley Peppel· 4 shared Benjamin PreeceiD· 3 shared Brian MacArthur· 2 shared Aaron Daurelle· 1 shared Abby Petersen· 1 shared Abby PetersoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBiophysics

Rodrigo Gallegos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cryo-ET Reveals Distinct Gag Lattice Architectures in Virus-like Particles and Immature HIV-1

Benjamin Preece, Wiley Peppel, Haley Durden, Rodrigo Gallegos, Gabriel Clinger, Nicole Bohn, Antje Huwendiek-Poser, Gillian Ysassi, Allyson Roman, Giovanna Garcia, Tasheena Cly, David M. Belnap, Saveez Saffarian

The paper uses cryo-electron tomography to compare Gag lattice structures in HIV-1 virus-like particles and immature virions, finding differences in lattice density, completeness, and curvature-Gag copy number correlation.

Structure · Apr 1, 2026Peer-reviewedBiophysics

A mechanism-aware stoichiometry platform resolves functional viral thresholds and induces antiviral hypersensitivity

Gabe Clinger, Haley Durden, Aaron Daurelle, Benjamin Preece, Wiley Peppel, Rodrigo Gallegos, Abdul A. Waheed, Nicole Bohne, Brian MacArthur, Abby Peterson, Ahmet Yıldız, Eric O. Freed, Saveez Saffarian

The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.

bioRxiv · Feb 10, 2026 · PreprintBiophysics

Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization

Aleksandar Atemin, Aneliya Ivanova, Wiley Peppel, Rumen Stamatov, Rodrigo Gallegos, Haley Durden, Sonya Uzunova, Michael D. Vershinin, Saveez Saffarian, Stoyno Stoynov

This study measures the kinetics of SARS-CoV-2 virus-like particle internalization using live-cell microscopy, revealing key steps and their timing, and showing no effect of Omicron mutations or S protein cleavage site on internalization rates.

Viruses · Aug 22, 2024Peer-reviewedCell Biology

Competitive assembly resolves the stoichiometry of essential proteins in infectious HIV-1 virions.

Haley Durden, Benjamin Preece, Rodrigo Gallegos, Ipsita Saha, Brian MacArthur, Abby Petersen, Wiley Peppel, Saveez Saffarian

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.

bioRxiv · Mar 10, 2024 · PreprintBiophysics