Author

Wiley Peppel

University of Utah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:cryo-EM· 3 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Rodrigo Gallegos· 4 shared Saveez SaffarianiD· 4 shared Benjamin PreeceiD· 3 shared Haley DurdeniD· 3 shared David M. BelnapiD· 2 shared Gabriel ClingeriD· 2 shared Gillian Ysassi· 2 shared Michael D. VershininiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersBiophysics

Rodrigo Gallegos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cryo-ET Reveals Distinct Gag Lattice Architectures in Virus-like Particles and Immature HIV-1

Benjamin Preece, Wiley Peppel, Haley Durden, Rodrigo Gallegos, Gabriel Clinger, Nicole Bohn, Antje Huwendiek-Poser, Gillian Ysassi, Allyson Roman, Giovanna Garcia, Tasheena Cly, David M. Belnap, Saveez Saffarian

The paper uses cryo-electron tomography to compare Gag lattice structures in HIV-1 virus-like particles and immature virions, finding differences in lattice density, completeness, and curvature-Gag copy number correlation.

Structure · Apr 1, 2026Peer-reviewedBiophysics

A mechanism-aware stoichiometry platform resolves functional viral thresholds and induces antiviral hypersensitivity

Gabe Clinger, Haley Durden, Aaron Daurelle, Benjamin Preece, Wiley Peppel, Rodrigo Gallegos, Abdul A. Waheed, Nicole Bohne, Brian MacArthur, Abby Peterson, Ahmet Yıldız, Eric O. Freed, Saveez Saffarian

The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.

bioRxiv · Feb 10, 2026 · PreprintBiophysics

Enhanced Yield and Gentle Purification of HIV for Cryo-Electron Tomography Analysis of Virion Maturation.

Benjamin Preece, Wiley Peppel, Rodrigo Gallegos, Gillian Ysassi, Gabriel Clinger, Nicole Bohn, Broti Adhikary, Luiza Mendonça, David M. Belnap, Michael D. Vershinin, Saveez Saffarian

This paper introduces a method for purifying HIV virions with high yield and minimal force, enabling detailed structural analysis of virion maturation.

Viruses · Mar 3, 2025Peer-reviewedMicrobiology

Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization

Aleksandar Atemin, Aneliya Ivanova, Wiley Peppel, Rumen Stamatov, Rodrigo Gallegos, Haley Durden, Sonya Uzunova, Michael D. Vershinin, Saveez Saffarian, Stoyno Stoynov

This study measures the kinetics of SARS-CoV-2 virus-like particle internalization using live-cell microscopy, revealing key steps and their timing, and showing no effect of Omicron mutations or S protein cleavage site on internalization rates.

Viruses · Aug 22, 2024Peer-reviewedCell Biology